Plasma Protein Regulation during COPD‐Related Muscle Wasting Using Mass Spectrometry‐Based Proteomics

0027. Kinetic of muscle mass regulation during experimental sepsis

Introduction Sepsis induced muscle weakness (SIMW) is associated with an important morbidity of critical care patients. Moreover, respiratory muscles weakness delays weaning from mechanical ventilation. The down-regulation of Akt pathway and the activation of proteolytic pathways, such as ubiquitin-proteasome or autophagy-lysosome pathways, could play a key role in the pathogenesis of SIMW. How...

Increased plasma Gln and Leu Ra and inappropriately low muscle protein synthesis rate in AIDS wasting.

Muscle protein wasting occurs in human immunodeficiency virus (HIV)-infected individuals and is often the initial indication of acquired immunodeficiency syndrome (AIDS). Little is known about the alterations in muscle protein metabolism that occur with HIV infection. Nine subjects with AIDS wasting (CD4 < 200/mm3), chronic stable opportunistic infections (OI), and ≥10% weight loss, fourteen HI...

Involvement of MicroRNAs in the Regulation of Muscle Wasting during Catabolic Conditions*

Loss of muscle proteins and the consequent weakness has important clinical consequences in diseases such as cancer, diabetes, chronic heart failure, and in aging. In fact, excessive proteolysis causes cachexia, accelerates disease progression, and worsens life expectancy. Muscle atrophy involves a common pattern of transcriptional changes in a small subset of genes named atrophy-related genes o...

Regulation of ATP-ubiquitin-dependent proteolysis in muscle wasting.

Protein breakdown plays a major role in muscle growth and atrophy. However, the regulation of muscle proteolysis by nutritional, hormonal and mechanical factors remains poorly understood. In this review, the methods available to study skeletal muscle protein breakdown, and our current understanding of the role of 3 major proteolytic systems that are well characterized in this tissue (ie the lys...

Protein Kinases in the Pathogenesis of Muscle Wasting